Research

Vytal Experience At Scale 

Deep Expertise Across Science, Engineering, and Commercialization

The eSensorem team combines deep domain expertise in wearable biosensors, electrochemical sensing, AI-driven analytics, and product commercialization. Our scientific leadership has pioneered multi-biomarker sweat sensing technologies, supported by over a decade of research and significant academic funding.

Vytal’s platform is built on more than a decade of research in proprietary, biocompatible sensor technology, leveraging advances in transepidermal water loss (TEWL), microfluidics, and lab-on-a-chip innovation. Our R&D efforts are led by Yangzhi Zhu, a leader in wearable bioelectronics, in collaboration with our Chief Technology Officer Gregor Berkowitz, who brings decades of Silicon Valley experience in translating breakthrough technologies into commercial successes across medical, diagnostic and consumer sectors. Together, they are refining and validating our multi-analyte biosensor to deliver non-invasive, real-time metabolic health insights, at scale.

Our executive team brings extensive experience from leading technology companies and high-growth startups, with a track record of building and scaling complex products across healthcare and consumer markets. Together, we are bridging the gap between advanced research and scalable, real-world health solutions.

Chief Scientist Yangzhi Zhu PhD.

Dr. Yangzhi Zhu is Chief Scientist at eSensorem and Principal Investigator at the Terasaki Institute for Biomedical Innovation (TIBI), where he leads pioneering research in wearable bioelectronics, biomaterials, and biosensing systems for continuous, non-invasive health monitoring. His work is focused on creating next-generation technologies that can seamlessly integrate with the human body to provide real-time biological insight and enable earlier, more personalized intervention.

Dr. Zhu earned his PhD in Chemical Engineering from the University of California, Riverside, and completed his postdoctoral training in nanoengineering at the University of California, San Diego. He has published in many of the world’s leading scientific journals, including Nature Biomedical Engineering, Nature Electronics, Nature Communications, Science Advances,and Science Translational Medicine。

At TIBI, Dr. Zhu leads an interdisciplinary research group working at the intersection of materials science, electrochemistry, bioengineering, and translational medicine. His lab develops wearable and biointegrated platforms that monitor important physiological and biochemical signals across multiple biofluids, including sweat, interstitial fluid, saliva, and tears. The goal of this work is to make health monitoring more continuous, accessible, and clinically actionable.

His research has produced innovations in electronic skin, microfluidic biosensors, lab-on-a-chip systems, and smart contact lens technologies for real-time physiological monitoring and responsive therapeutic delivery. These advances are helping lay the foundation for a new era of precision health, in which diseases can be detected earlier, monitored more closely, and managed more effectively through low-burden, real-world technologies.

In recognition of his contributions, Dr. Zhu received the 2024 NARSAD Young Investigator Award for his contributions to smart materials and wearable technologies, 2025 Biosensors Young Investigator Award for excellence in flexible biosensor development and electronic skin platforms, the 2026 ACS Materials Au Rising Star, and the 2026 American Heart Association (AHA) Career Development Award supporting research in organ health assessment and biosensing-driven diagnostics and .

Through his scientific leadership and translational vision, he is helping shape a future in which bioelectronic technologies bring proactive, personalized care closer to everyday life.

 

    Full Research List of Dr. Yangzhi Zhu
    Google Scholar Citations (Updated)

    Technology roadmap for flexible sensors

    Y Luo, MR Abidian, JH Ahn, D Akinwande, AM Andrews, M Antonietti, …
    ACS nano 17 (6), 5211-5295
    1282 2023

    Additively manufactured metallic biomaterials

    E Davoodi, H Montazerian, AS Mirhakimi, M Zhianmanesh, O Ibhadode, …
    Bioactive Materials 15, 214-249
    286 2022

    Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing

    C Wang, X Jiang, HJ Kim, S Zhang, X Zhou, Y Chen, H Ling, Y Xue, …
    Biomaterials 285, 121479
    206 2022

    Capillary-force-assisted clean-stamp transfer of two-dimensional materials

    X Ma, Q Liu, D Xu, Y Zhu, S Kim, Y Cui, L Zhong, M Liu
    Nano letters 17 (11), 6961-6967
    178 2017

    Stretchable ultrasonic arrays for the three-dimensional mapping of the modulus of deep tissue

    H Hu, Y Ma, X Gao, D Song, M Li, H Huang, X Qian, R Wu, K Shi, H Ding, …
    Nature Biomedical Engineering 7 (10), 1321-1334
    138 2023

    A photoacoustic patch for three-dimensional imaging of hemoglobin and core temperature

    X Gao, X Chen, H Hu, X Wang, W Yue, J Mu, Z Lou, R Zhang, K Shi, …
    Nature Communications 13 (1), 7757
    133 2022

    A breathable, passive‐cooling, non‐inflammatory, and biodegradable aerogel electronic skin for wearable physical‐electrophysiological‐chemical analysis

    Y Zhu, R Haghniaz, MC Hartel, S Guan, J Bahari, Z Li, A Baidya, K Cao, …
    Advanced Materials 35 (10), 2209300
    122 2023

    Lab‐on‐a‐Contact lens: Recent advances and future opportunities in diagnostics and therapeutics

    Y Zhu, S Li, J Li, N Falcone, Q Cui, S Shah, MC Hartel, N Yu, P Young, …
    Advanced Materials 34 (24), 2108389
    120 2022

    Polybenzimidazole membranes with nanophase-separated structure induced by non-ionic hydrophilic side chains for vanadium flow batteries

    S Peng, X Wu, X Yan, L Gao, Y Zhu, D Zhang, J Li, Q Wang, G He
    Journal of Materials Chemistry A 6 (9), 3895-3905
    120 2018

    Harnessing the wide-range strain sensitivity of bilayered PEDOT: PSS films for wearable health monitoring

    H Liu, S Zhang, Z Li, TJ Lu, H Lin, Y Zhu, S Ahadian, S Emaminejad, …
    Matter 4 (9), 2886-2901
    118 2021

    Aerogel‐based biomaterials for biomedical applications: from fabrication methods to disease‐targeting applications

    S Karamikamkar, EP Yalcintas, R Haghniaz, NR de Barros, M Mecwan, …
    Advanced Science 10 (23), 2204681
    115 2023

    Smart contact lenses for biosensing applications

    X Ma, S Ahadian, S Liu, J Zhang, S Liu, T Cao, W Lin, D Wu, …
    Advanced Intelligent Systems 3 (5), 2000263
    112 2021

    Organ‐on‐a‐chip models of the blood–brain barrier: recent advances and future prospects

    S Kawakita, K Mandal, L Mou, MM Mecwan, Y Zhu, S Li, S Sharma, …
    Small 18 (39), 2201401
    109 2022

    High external-efficiency nanofocusing for lens-free near-field optical nanoscopy

    S Kim, N Yu, X Ma, Y Zhu, Q Liu, M Liu, R Yan
    Nature Photonics 13 (9), 636-643
    105 2019

    State of the art in integrated biosensors for organ-on-a-chip applications

    Y Zhu, K Mandal, AL Hernandez, S Kawakita, W Huang, P Bandaru, …
    Current Opinion in Biomedical Engineering 19, 100309
    102 2021

    Tissue adhesive hemostatic microneedle arrays for rapid hemorrhage treatment

    R Haghniaz, HJ Kim, H Montazerian, A Baidya, M Tavafoghi, Y Chen, …
    Bioactive Materials 23, 314-327
    81 2023

    Recent developments in mussel-inspired materials for biomedical applications

    NR Barros, Y Chen, V Hosseini, W Wang, R Nasiri, M Mahmoodi, …
    Biomaterials science 9 (20), 6653-6672
    75 2021

    Ion conductive mechanisms and redox flow battery applications of polybenzimidazole-based membranes

    Y Chen, P Xiong, S Xiao, Y Zhu, S Peng, G He
    Energy Storage Materials 45, 595-617
    74 2022

    Epidermis‐inspired wearable piezoresistive pressure sensors using reduced graphene oxide self‐wrapped copper nanowire networks

    Y Zhu, MC Hartel, N Yu, PR Garrido, S Kim, J Lee, P Bandaru, S Guan, …
    Small Methods 6 (1), 2100900
    71 2022
    A wearable echomyography system based on a single transducer

     

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